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Official Description

Gases, blood, O2 saturation only, by direct measurement, except pulse oximetry

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82810 refers to a laboratory test specifically designed to measure blood oxygen saturation (O2 saturation) through direct measurement methods, excluding the use of pulse oximetry. Oxygen saturation is a critical parameter that indicates the percentage of hemoglobin in the blood that is currently bound to oxygen. This measurement is essential in various clinical settings, particularly for patients who are critically ill or have compromised tissue perfusion, as it provides vital information regarding their respiratory and circulatory status. The direct measurement of O2 saturation is typically conducted using a blood gas analyzer equipped with CO-oximetry technology, which allows for accurate assessment of the oxygen levels in the blood. To perform this test, a blood sample must be collected, which can be obtained through various methods such as venipuncture, heel stick, arterial draw, or umbilical cord draw, depending on the patient's condition and age. This procedure is crucial for monitoring and managing patients' oxygenation status, guiding treatment decisions, and ensuring appropriate interventions are implemented in a timely manner.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 82810 is indicated for several clinical scenarios where accurate measurement of blood oxygen saturation is necessary. These indications include:

  • Assessment of Oxygenation Status This test is performed to evaluate the oxygen saturation levels in patients, particularly those who are critically ill or have respiratory distress.
  • Monitoring of Patients with Poor Tissue Perfusion It is essential for determining oxygen saturation in patients exhibiting signs of inadequate blood flow to tissues, which can affect their overall health and treatment outcomes.
  • Correlation with External Monitoring Devices The measurement may be conducted to validate or correlate the readings obtained from external monitoring devices, such as pulse oximeters, ensuring accuracy in patient monitoring.

2. Procedure

The procedure for CPT® Code 82810 involves several critical steps to ensure accurate measurement of blood oxygen saturation. These steps include:

  • Sample Collection A blood sample is obtained from the patient using one of several methods, which may include venipuncture, heel stick, arterial draw, or umbilical cord draw. The choice of method depends on the patient's age, condition, and the clinical setting.
  • Direct Measurement Once the blood sample is collected, it is analyzed using a blood gas analyzer that incorporates CO-oximetry technology. This technology allows for the direct measurement of the oxygen saturation levels in the blood, providing precise and reliable results.
  • Result Interpretation The results of the oxygen saturation measurement are then interpreted by healthcare professionals to assess the patient's respiratory function and overall oxygenation status. This information is crucial for making informed clinical decisions regarding patient care.

3. Post-Procedure

After the procedure associated with CPT® Code 82810, the patient may require monitoring based on the results obtained from the blood oxygen saturation measurement. If the levels indicate hypoxemia or other abnormalities, further interventions may be necessary, such as supplemental oxygen therapy or additional diagnostic testing. It is also important to document the findings accurately in the patient's medical record to ensure continuity of care and facilitate any necessary follow-up actions. The healthcare provider should assess the site of blood collection for any complications, such as bleeding or infection, and provide appropriate post-procedure care instructions to the patient or caregiver.

Short Descr BLOOD GASES O2 SAT ONLY
Medium Descr GASES BLOOD O2 SATURATION ONLY DIRECT MEAS
Long Descr Gases, blood, O2 saturation only, by direct measurement, except pulse oximetry
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 205 - Arterial blood gases
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GW Service not related to the hospice patient's terminal condition
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
Date
Action
Notes
2011-01-01 Changed Short description changed.
1994-01-01 Added First appearance in code book in 1994.
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