CPT® Code 84585

A urine test is conducted to assess the levels of vanillylmandelic acid (VMA), which is a significant metabolite derived from the catecholamine hormones, specifically epinephrine and norepinephrine. These hormones are produced by the adrenal glands and play crucial roles in the body's response to stress and regulation of various physiological functions. The measurement of VMA levels in urine is important as it can provide insights into the functioning of the adrenal glands and the presence of certain medical conditions. It is normal for VMA levels to exhibit small fluctuations; however, mildly elevated levels can occur due to various factors such as hypertension, anxiety, physical exercise, and the intake of certain over-the-counter (OTC) medications and herbal supplements. Significantly higher levels of VMA may indicate the presence of neuroendocrine tumors, including neuroblastoma or pheochromocytoma, which are conditions that require further investigation. This test is not only utilized for diagnosing these disorders but also for monitoring the effectiveness of ongoing treatment. To perform the test, either a 24-hour urine specimen or a random urine sample is collected and subsequently analyzed using quantitative high-performance liquid chromatography, a precise method that allows for accurate measurement of VMA levels.