CPT® Code 84143

The CPT® Code 84143 refers to the laboratory test for measuring levels of 17-hydroxypregnenolone, a steroid hormone that plays a crucial role in the synthesis of other hormones, including cortisol and sex steroids. This complex molecule is classified as a C-21 steroid and is produced primarily in the adrenal glands and gonads through a biochemical process known as hydroxylation of pregnenolone. The measurement of 17-hydroxypregnenolone is significant as its levels peak at the end of puberty and subsequently decline with age. Notably, during pregnancy, the levels of this hormone increase, reflecting its involvement in various physiological processes. The test is particularly valuable in clinical settings for diagnosing congenital adrenal hyperplasia, a genetic disorder affecting adrenal hormone production. Additionally, it is utilized to evaluate women presenting with symptoms such as hirsutism, which is excessive hair growth, and infertility, providing essential information for further medical assessment and management. The test is conducted by obtaining a blood sample through venipuncture, which is a separately reportable procedure. The serum or plasma obtained from the blood sample is then analyzed using advanced techniques such as quantitative high-performance liquid chromatography-tandem mass spectrometry, ensuring accurate and reliable measurement of hormone levels.