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Official Description

Homovanillic acid (HVA)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83150 refers to the measurement of homovanillic acid (HVA) levels in urine. HVA is a significant metabolite of catecholamines, which are hormones produced by the adrenal glands in response to stress. This test is particularly important as elevated levels of HVA can indicate various medical conditions, including neuroblastoma, a type of cancer that commonly affects children, and malignant pheochromocytoma, a tumor of the adrenal gland that can lead to excessive production of catecholamines. Additionally, HVA levels may be influenced by several other factors such as hypertension, anxiety, and intense physical activity, as well as the use of certain prescription and over-the-counter medications. It is noteworthy that smoking can lead to markedly decreased levels of HVA in the urine. For the test, a random voided urine sample or a 24-hour urine specimen is collected, and the analysis is performed using quantitative high-performance liquid chromatography, a precise method that allows for accurate measurement of HVA concentrations in the urine.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The measurement of homovanillic acid (HVA) levels in urine is indicated for the following conditions:

  • Neuroblastoma This test is performed to help diagnose neuroblastoma, a malignant tumor that arises from nerve tissue, primarily affecting children.
  • Malignant Pheochromocytoma HVA levels may be evaluated in patients suspected of having malignant pheochromocytoma, a tumor that secretes catecholamines and can lead to serious health complications.
  • Metabolic Stress Elevated HVA levels can indicate the body's response to metabolic stress, which may warrant further investigation.
  • Hypertension The test may be indicated in patients with hypertension to assess potential underlying causes related to catecholamine production.
  • Anxiety Anxiety can influence catecholamine levels, and measuring HVA may provide insights into the physiological response to stress.
  • Intense Physical Activity HVA levels may be elevated following intense physical exertion, making this test relevant for athletes or individuals undergoing rigorous training.

2. Procedure

The procedure for measuring homovanillic acid (HVA) levels in urine involves several key steps:

  • Specimen Collection A urine specimen is collected, which can either be a random voided sample or a 24-hour urine collection. For a 24-hour collection, the patient is instructed to collect all urine produced over a 24-hour period to ensure accurate measurement of HVA levels.
  • Sample Preparation Once the urine specimen is collected, it is prepared for analysis. This may involve centrifugation or other methods to ensure that the sample is suitable for testing.
  • Quantitative Analysis The prepared urine sample is then analyzed using quantitative high-performance liquid chromatography (HPLC). This sophisticated technique allows for the precise measurement of HVA concentrations in the urine, providing reliable results for clinical interpretation.

3. Post-Procedure

After the urine specimen has been analyzed for homovanillic acid levels, the results are typically reviewed by a healthcare professional. Depending on the findings, further diagnostic testing or clinical evaluations may be recommended. It is important for patients to discuss the results with their physician to understand the implications and any necessary follow-up actions. Additionally, patients may be advised to refrain from certain activities or medications that could affect HVA levels prior to testing, such as avoiding intense physical activity or specific drugs that may influence catecholamine metabolism.

Short Descr ASSAY OF HOMOVANILLIC ACID
Medium Descr ASSAY OF HOMOVANILLIC ACID
Long Descr Homovanillic acid (HVA)
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GA Waiver of liability statement issued as required by payer policy, individual case
Date
Action
Notes
2013-01-01 Changed Description Changed
Pre-1990 Added Code added.
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