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Official Description

Nickel

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83885 refers to a laboratory test specifically designed to measure the levels of nickel in the body, which can be conducted using either blood or urine samples. Nickel is a heavy metal that, while essential in trace amounts for certain biological functions, can become toxic when present in excessive quantities. This toxicity is a significant concern as nickel can enter the human body through various environmental sources, including contaminated food, water, and air. The testing process involves obtaining a blood sample through a procedure known as venipuncture, which is a separate and reportable action. Alternatively, urine samples can be collected either as a random voided sample or as a 24-hour specimen, depending on the testing requirements. The analysis of both serum and urine samples is performed using a sophisticated technique called quantitative inductively coupled plasma-mass spectrometry (ICP-MS), which allows for precise measurement of nickel concentrations. This test is crucial for diagnosing potential nickel exposure and toxicity, guiding further medical evaluation and management.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The nickel test (CPT® Code 83885) is indicated for the assessment of nickel exposure and potential toxicity. The following conditions may warrant this testing:

  • Occupational Exposure Individuals working in industries where nickel is used or processed may require testing to monitor exposure levels.
  • Environmental Exposure Patients living in areas with high environmental nickel pollution may be tested to evaluate potential health risks.
  • Symptoms of Toxicity Symptoms such as respiratory issues, skin rashes, or systemic reactions may prompt testing for nickel levels.

2. Procedure

The procedure for testing nickel levels involves several key steps, which are outlined below:

  • Step 1: Sample Collection A blood sample is obtained through venipuncture, which involves inserting a needle into a vein to draw blood. This step is critical as it provides the serum needed for analysis. Alternatively, urine samples can be collected, either as a random voided sample or as a 24-hour specimen, depending on the specific requirements of the test.
  • Step 2: Sample Preparation Once the blood and urine samples are collected, they must be properly prepared for analysis. This may involve centrifugation of the blood sample to separate the serum from the cellular components, ensuring that only the serum is tested for nickel levels.
  • Step 3: Analytical Testing The prepared serum and urine samples are then subjected to quantitative inductively coupled plasma-mass spectrometry (ICP-MS). This advanced analytical technique allows for the precise measurement of nickel concentrations in the samples, providing accurate results that reflect the levels of nickel present in the body.

3. Post-Procedure

After the nickel testing procedure, there are generally no specific post-procedure care requirements for patients. However, it is important for healthcare providers to review the test results with the patient to discuss any potential implications of elevated nickel levels. If elevated levels are detected, further evaluation and management may be necessary to address potential sources of exposure and to mitigate any health risks associated with nickel toxicity. Patients should be advised to follow up with their healthcare provider for interpretation of results and any recommended next steps.

Short Descr ASSAY OF NICKEL
Medium Descr ASSAY OF NICKEL
Long Descr Nickel
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 206 - Microscopic examination (bacterial smear, culture, toxicology)
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GA Waiver of liability statement issued as required by payer policy, individual case
Date
Action
Notes
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
Code
Description
Code
Description
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