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The CPT® Code 83570 refers to a laboratory test that measures the level of isocitric dehydrogenase (IDH), an important enzyme involved in cellular metabolism. Isocitric dehydrogenase plays a critical role in the citric acid cycle, a key metabolic pathway that generates energy through the oxidative decarboxylation of isocitrate, resulting in the formation of alpha-ketoglutarate and carbon dioxide (CO2). This enzymatic reaction is essential for the conversion of NAD(P)+ to NAD(P)H, which is vital for various cellular processes. The activity of IDH occurs in multiple cellular compartments, including the cytosol, mitochondria, and peroxisomes, highlighting its significance in diverse metabolic functions. The enzyme is not only crucial for energy production but also for lipid synthesis, oxygen sensing, signal transduction, and providing cellular defense against oxidative stress. Furthermore, mutations in the IDH gene have been linked to certain human cancers, such as gliomas and acute myeloid leukemia, underscoring the clinical relevance of measuring IDH levels in diagnostic and therapeutic contexts.
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The measurement of isocitric dehydrogenase (IDH) levels is indicated in various clinical scenarios, particularly in the context of certain malignancies and metabolic disorders. The following conditions may warrant the performance of this laboratory test:
The procedure for measuring isocitric dehydrogenase (IDH) levels involves several key steps to ensure accurate and reliable results. The following outlines the procedural steps:
After the procedure, the patient may be advised on any necessary follow-up actions based on the results of the IDH test. If elevated levels of IDH are detected, further diagnostic evaluations or consultations with oncologists or specialists may be recommended to explore potential underlying conditions, particularly in the context of cancer. Additionally, patients may be monitored for any symptoms or complications related to their condition, and appropriate treatment plans may be developed based on the findings from the IDH level assessment.
| Short Descr | ASSAY OF IDH ENZYME | Medium Descr | ISOCITRIC DEHYDROGENASE | Long Descr | Isocitric dehydrogenase (IDH) | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
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| Pre-1990 | Added | Code added. |
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