CPT® Code 84228

The CPT® Code 84228 refers to a laboratory test that measures the levels of quinine in the blood or urine. Quinine is a compound that is naturally derived from the bark of cinchona trees and is well-known for its use in tonic water, a popular beverage. This test is significant in clinical settings as quinine is utilized for various medical conditions, including malaria, systemic lupus erythematosus (SLE), arthritis, and nocturnal leg cramps. Additionally, quinine possesses anti-pyretic properties, meaning it can help reduce fever, as well as anti-inflammatory effects, which can be beneficial in managing certain inflammatory conditions. The testing process involves obtaining a blood sample through a procedure known as venipuncture, which is separately reportable, and a urine sample collected via random voiding. The analysis of both serum or plasma and urine samples is conducted using advanced techniques such as high-performance liquid chromatography coupled with tandem mass spectrometry, ensuring accurate measurement of quinine levels in the body.