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Official Description

Chloramphenicol

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82415 refers to the laboratory test for chloramphenicol, a broad-spectrum antibiotic that is utilized in the treatment of serious bacterial infections. This blood test is specifically designed to monitor the therapeutic drug levels of chloramphenicol in a patient's system. Monitoring is crucial because elevated levels of chloramphenicol can lead to significant adverse effects, including bone marrow suppression, which is typically reversible, and aplastic anemia, a potentially fatal condition. The procedure involves obtaining a blood sample through venipuncture, which is a separate reportable procedure. The analysis of the serum or plasma is conducted using high-performance liquid chromatography (HPLC), a sophisticated technique that allows for precise measurement of drug concentrations in the blood. This testing is essential for ensuring that patients receive the appropriate dosage of chloramphenicol while minimizing the risk of serious side effects associated with its use.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The blood test for chloramphenicol (CPT® Code 82415) is indicated for the following conditions:

  • Monitoring Therapeutic Levels This test is performed to ensure that the levels of chloramphenicol in the patient's bloodstream remain within the therapeutic range, which is essential for effective treatment.
  • Assessment of Side Effects It is used to monitor for potential side effects associated with chloramphenicol, particularly bone marrow suppression and aplastic anemia, which can occur with elevated drug levels.
  • Management of Serious Infections The test is indicated for patients receiving chloramphenicol for the treatment of serious infections, allowing healthcare providers to adjust dosages as necessary based on the test results.

2. Procedure

The procedure for testing chloramphenicol levels involves several key steps:

  • Step 1: Patient Preparation Prior to the blood draw, the patient may be instructed to avoid certain medications or foods that could interfere with the test results. It is important to ensure that the patient is adequately informed about the procedure.
  • Step 2: Venipuncture A qualified healthcare professional performs a venipuncture to obtain a blood sample. This involves inserting a needle into a vein, typically in the arm, to collect the necessary volume of blood for testing. The venipuncture is a separately reportable procedure and must be documented accordingly.
  • Step 3: Sample Processing Once the blood sample is collected, it is processed to separate the serum or plasma from the cellular components. This step is crucial for accurate testing.
  • Step 4: High-Performance Liquid Chromatography (HPLC) The serum or plasma is then analyzed using high-performance liquid chromatography, a precise method that allows for the quantification of chloramphenicol levels in the sample. This technique is essential for determining whether the drug concentration is within the therapeutic range.

3. Post-Procedure

After the procedure, the patient may experience minor discomfort at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care instructions related to the blood test itself; however, healthcare providers should monitor the patient for any signs of adverse reactions to chloramphenicol, especially if elevated levels are detected. The results of the test will guide further treatment decisions, including potential dosage adjustments to mitigate the risk of side effects associated with high drug levels.

Short Descr ASSAY OF CHLORAMPHENICOL
Medium Descr CHLORAMPHENICOL
Long Descr Chloramphenicol
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
Date
Action
Notes
Pre-1990 Added Code added.
Code
Description
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