CPT® Code 83864

The CPT® Code 83864 refers to a quantitative test for acid mucopolysaccharides, which are also known as glycosaminoglycans (GAGs). These are long-chain sugar molecules that play a crucial role in the structure and function of various tissues in the body, including bone, connective tissue, and joint fluid. The test is primarily conducted on a urine sample to assess the levels of these mucopolysaccharides. Conditions such as mucopolysaccharidosis (MPS) arise from genetically inherited metabolic syndromes, including Hunter syndrome, Hurler syndrome, Sanfilippo syndrome, Scheie syndrome, and Morquio syndrome. These syndromes are characterized by a deficiency of specific enzymes that are responsible for breaking down the sugar molecule chains, leading to an accumulation of mucopolysaccharides in the body. The quantitative test indicated by CPT® Code 83864 is particularly important for monitoring patients who have already been diagnosed with MPS, as it helps in tracking the levels of GAGs over time. For optimal results, a urine specimen is typically collected as the first morning void, although a 24-hour urine specimen may also be utilized. The analysis of the urine sample is performed using spectrophotometry, a method that measures the intensity of light absorbed by the sample, providing a quantitative assessment of the acid mucopolysaccharide levels present.