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Official Description

Manganese

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83785 refers to the laboratory test for measuring manganese levels in blood or urine. Manganese is an essential trace mineral that plays a critical role in various physiological functions within the body. It is predominantly found in tissues such as bone, liver, pancreas, and kidneys. This mineral acts as a cofactor for several enzymes, which are vital for detoxifying free radicals, thereby protecting cells from oxidative stress. Additionally, manganese is necessary for the formation of bone and connective tissue, as well as for the synthesis of blood clotting factors and sex hormones. Beyond structural roles, manganese is involved in metabolic processes, including the metabolism of fats and carbohydrates, and it helps regulate blood glucose levels. Furthermore, it contributes to the proper functioning of brain and nerve cells, highlighting its importance in neurological health. The test for manganese levels can be performed using a blood sample obtained through venipuncture, which is a separately reportable procedure. Alternatively, urine specimens can be collected either as a random void or as a 24-hour specimen. The analysis of serum, whole blood, and urine samples is conducted using quantitative inductively coupled plasma-mass spectrometry, a highly sensitive and accurate method for measuring trace elements in biological samples.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The manganese test (CPT® Code 83785) is indicated for the assessment of manganese levels in the body, which may be necessary under the following circumstances:

  • Exposure Assessment - To evaluate potential manganese exposure in individuals who may have been exposed to manganese through occupational or environmental sources.
  • Symptoms of Deficiency or Toxicity - To investigate symptoms that may suggest manganese deficiency, such as impaired bone formation or metabolic issues, or symptoms of manganese toxicity, which can include neurological problems.
  • Monitoring Treatment - To monitor manganese levels in patients undergoing treatment that may affect manganese metabolism or excretion.

2. Procedure

The procedure for obtaining manganese levels involves several key steps, which are outlined below:

  • Step 1: Sample Collection - A blood sample is obtained through venipuncture, which is a procedure where a needle is inserted into a vein to draw blood. This step is crucial as it provides the serum or whole blood needed for the manganese analysis. Alternatively, urine samples can be collected, which may be either a random void or a 24-hour specimen, depending on the clinical requirements.
  • Step 2: Sample Preparation - Once the blood or urine samples are collected, they are prepared for analysis. This may involve centrifugation of the blood sample to separate the serum from the cellular components, ensuring that the analysis is performed on the appropriate sample type.
  • Step 3: Analytical Testing - The prepared serum, whole blood, or urine samples are then subjected to quantitative inductively coupled plasma-mass spectrometry (ICP-MS). This advanced analytical technique allows for the precise measurement of manganese levels, providing accurate results that reflect the patient's manganese status.

3. Post-Procedure

After the manganese testing procedure, there are generally no specific post-procedure care requirements for patients. However, it is important for healthcare providers to communicate the results to the patient and discuss any necessary follow-up actions based on the findings. If the test indicates abnormal manganese levels, further evaluation or intervention may be warranted to address potential deficiencies or toxicities. Patients should also be informed about the importance of reporting any symptoms that may arise following the test, especially if they are related to manganese metabolism.

Short Descr ASSAY OF MANGANESE
Medium Descr ASSAY OF MANGANESE
Long Descr Manganese
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GA Waiver of liability statement issued as required by payer policy, individual case
GZ Item or service expected to be denied as not reasonable and necessary
Date
Action
Notes
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
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