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Official Description

Manganese

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83785 refers to the laboratory test for measuring manganese levels in blood or urine. Manganese is an essential trace mineral that plays a critical role in various physiological functions within the body. It is predominantly found in tissues such as bone, liver, pancreas, and kidneys. This mineral acts as a cofactor for several enzymes, which are vital for detoxifying free radicals, thereby protecting cells from oxidative stress. Additionally, manganese is necessary for the formation of bone and connective tissue, as well as for the synthesis of blood clotting factors and sex hormones. Beyond structural roles, manganese is involved in metabolic processes, including the metabolism of fats and carbohydrates, and it helps regulate blood glucose levels. Furthermore, it contributes to the proper functioning of brain and nerve cells, highlighting its importance in neurological health. The test for manganese levels can be performed using a blood sample obtained through venipuncture, which is a separately reportable procedure. Alternatively, urine specimens can be collected either as a random void or as a 24-hour specimen. The analysis of serum, whole blood, and urine samples is conducted using quantitative inductively coupled plasma-mass spectrometry, a highly sensitive and accurate method for measuring trace elements in biological samples.

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