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Official Description

Natriuretic peptide

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83880 refers to the measurement of natriuretic peptide levels in the blood, a critical diagnostic tool used primarily in the evaluation of heart failure. Natriuretic peptides are hormones produced by the heart in response to increased pressure that often occurs in heart failure. This test is essential for differentiating heart failure from other conditions that may present with similar symptoms, such as pulmonary disorders or renal issues. The procedure involves a venipuncture, where blood is drawn from a patient, and the collected sample is treated with EDTA, an anticoagulant that prevents clotting. Following this, an automated immunoassay is conducted, utilizing specific antibodies that are designed to bind to natriuretic peptides. These antibodies are tagged with a fluorescent dye, allowing for precise measurement of the peptide levels in the sample. The results of this analysis are then reviewed by a physician, who uses the information to inform diagnosis and guide treatment decisions for the patient.

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