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The CPT® Code 84220 refers to a laboratory test that measures the levels of pyruvate kinase, an important enzyme that plays a critical role in the metabolic pathway known as glycolysis. This enzyme is essential for the conversion of glucose into energy within the body's cells. A deficiency in pyruvate kinase can result from a genetic defect, which can significantly impact the body's ability to produce glucose from non-carbohydrate sources, a process known as gluconeogenesis. This deficiency is particularly relevant in erythrocytes, or red blood cells, where it can lead to hemolytic anemia, a condition characterized by the premature destruction of red blood cells. The test is performed on a blood sample that is obtained through a procedure known as venipuncture, which is separately reportable. The analysis of the blood sample is conducted using a quantitative enzymatic method, allowing for precise measurement of pyruvate kinase levels in the bloodstream.
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The pyruvate kinase test is indicated for the evaluation of patients who may have a deficiency of the enzyme, which can lead to various clinical conditions. The following are specific indications for performing this test:
The procedure for measuring pyruvate kinase levels involves several key steps, which are outlined below:
After the blood sample has been collected, the patient may experience minor discomfort or bruising at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care instructions required for this test, but patients should be advised to report any unusual symptoms or prolonged discomfort. The results of the pyruvate kinase test will be interpreted by a healthcare provider, who will discuss the findings with the patient and determine any necessary follow-up actions based on the results.
| Short Descr | ASSAY OF PYRUVATE KINASE | Medium Descr | ASSAY OF PYRUVATE KINASE | Long Descr | Pyruvate kinase | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | 91 | Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient. | GV | Attending physician not employed or paid under arrangement by the patient's hospice provider | Q4 | Service for ordering/referring physician qualifies as a service exemption |
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| 2013-01-01 | Changed | Medium Descriptor changed. |
| Pre-1990 | Added | Code added. |
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