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Official Description

Carbohydrate deficient transferrin

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82373 refers to the laboratory test for carbohydrate deficient transferrin (CDT), which serves as a significant biomarker for chronic alcohol consumption. This test is particularly relevant in identifying individuals who may be heavy consumers of alcohol, as CDT levels are elevated in those who consume alcohol in excess of 50 grams per day for a duration exceeding two weeks. The presence of CDT in the blood can indicate a pattern of alcohol use that may be detrimental to health. Additionally, this test can be utilized in the evaluation of patients with poorly controlled or uncontrolled diabetes mellitus, aiding in the diagnosis of congenital glycosylation disorders. The testing process involves obtaining a blood sample through venipuncture, which is a procedure that can be reported separately. Following sample collection, the serum is analyzed using electrophoresis for cases related to chronic alcohol use, while affinity chromatography coupled with mass spectrometry is employed for assessing congenital glycosylation. This comprehensive approach ensures accurate detection and diagnosis based on the specific clinical context of the patient.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The carbohydrate deficient transferrin (CDT) test is indicated for the following conditions:

  • Chronic Alcohol Consumption This test is performed to assess individuals suspected of being heavy consumers of alcohol, specifically those who may consume more than 50 grams of alcohol per day for a period longer than two weeks.
  • Poorly Controlled Diabetes Mellitus CDT testing may also be indicated in patients with poorly controlled or uncontrolled diabetes mellitus to aid in the diagnosis of congenital glycosylation disorders.

2. Procedure

The procedure for testing carbohydrate deficient transferrin involves several key steps that ensure accurate results:

  • Step 1: Blood Sample Collection A blood sample is obtained from the patient through a process known as venipuncture. This involves inserting a needle into a vein, typically in the arm, to draw blood. The sample must be collected in a manner that adheres to standard laboratory protocols to ensure the integrity of the specimen.
  • Step 2: Serum Preparation Once the blood sample is collected, it is allowed to clot, and then the serum is separated from the cellular components. This serum is the portion of the blood that will be tested for carbohydrate deficient transferrin levels.
  • Step 3: Electrophoresis Testing For patients suspected of chronic alcohol use, the serum is analyzed using electrophoresis. This technique separates proteins based on their size and charge, allowing for the identification of carbohydrate deficient transferrin levels in the sample.
  • Step 4: Affinity Chromatography/Mass Spectrometry In cases where congenital glycosylation is suspected, the testing may involve affinity chromatography followed by mass spectrometry. This advanced method provides a detailed analysis of the glycosylation patterns in the serum, aiding in the diagnosis of specific disorders.

3. Post-Procedure

After the procedure, the patient may experience minimal discomfort at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care instructions required for the CDT test; however, patients should be informed about the importance of following up with their healthcare provider to discuss the test results. The results of the CDT test can provide critical insights into the patient's alcohol consumption patterns and potential underlying health issues, guiding further clinical management and intervention as necessary.

Short Descr ASSAY C-D TRANSFER MEASURE
Medium Descr CARBOHYDRATE DEFICIENT TRANSFERRIN
Long Descr Carbohydrate deficient transferrin
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
Q4 Service for ordering/referring physician qualifies as a service exemption
Date
Action
Notes
2011-01-01 Changed Short description changed.
2001-01-01 Added First appearance in code book in 2001.
Code
Description
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