CPT® Code 83835

The CPT® Code 83835 refers to the measurement of metanephrines, which are metabolites of epinephrine, a hormone produced by the adrenal glands. This procedure involves either a blood or urine test to assess the levels of metanephrines in the body. Elevated levels of metanephrines can indicate the presence of neuroendocrine tumors, such as pheochromocytomas, which are tumors that can affect the adrenal glands and lead to excessive production of catecholamines. Additionally, metanephrine levels may rise due to intense physical exercise, physiological stress from serious illnesses, or the ingestion of certain substances, including drugs like epinephrine, caffeine, and alcohol. The testing process requires a blood sample, which is obtained through a venipuncture that must be reported separately. For plasma testing, quantitative liquid chromatography-tandem mass spectrometry is utilized, while for urine testing, either a random voided specimen or a 24-hour urine collection is analyzed using quantitative high-performance liquid chromatography-tandem mass spectrometry. This comprehensive approach ensures accurate measurement of metanephrine levels, aiding in the diagnosis and management of conditions related to abnormal catecholamine production.