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The CPT® Code 83498 refers to the measurement of 17-hydroxyprogesterone (17-OHP), a hormone that plays a crucial role in the body's endocrine system. This test is typically performed through a blood or urine sample to assess the levels of 17-OHP, which is primarily produced in the adrenal glands and the corpus luteum of the ovary. The measurement of 17-OHP is particularly significant in the context of congenital adrenal hyperplasia (CAH), a genetic disorder that affects adrenal gland function, as elevated levels of this hormone can indicate the presence of this condition in infants. Consequently, the 17-OHP test is often included in newborn screening panels to ensure early detection and management of CAH. In adults, the levels of 17-OHP can be influenced by various factors, including the presence of adrenal and ovarian tumors, polycystic ovarian syndrome (PCOS), and physiological changes during pregnancy, particularly in the third trimester. The test can be performed using a blood sample obtained through venipuncture, which is a standard method for collecting blood. For infants, a less invasive approach, such as the heel stick or capillary method, may be utilized to draw blood. The analysis of the collected serum or plasma is typically conducted using advanced techniques such as quantitative high-performance liquid chromatography-tandem mass spectrometry or quantitative radioimmunoassay, which provide accurate measurements of hormone levels. Alternatively, a 24-hour urine specimen may be collected and analyzed using radioimmunoassay, offering another method for assessing 17-OHP levels in the body.
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The 17-hydroxyprogesterone (17-OHP) test is indicated for several clinical scenarios, particularly in the evaluation of hormonal imbalances and conditions related to adrenal and reproductive health. The following are the primary indications for performing this test:
The procedure for measuring 17-hydroxyprogesterone (17-OHP) involves several key steps to ensure accurate results. The following outlines the procedural steps involved:
After the procedure, patients may be advised on specific post-collection care, particularly if venipuncture was performed. It is common for patients to experience minor discomfort or bruising at the site of blood draw, which typically resolves on its own. For infants, caregivers should monitor the heel stick site for any signs of excessive bleeding or infection. Results from the 17-OHP test are usually available within a few days, and healthcare providers will discuss the findings with the patient or the infant's caregivers to determine any necessary follow-up actions or treatments based on the results. It is important to note that further testing may be required if abnormal levels of 17-OHP are detected, to confirm a diagnosis or to rule out other conditions.
| Short Descr | ASY HYDROXYPROGESTERONE 17-D | Medium Descr | ASSAY OF HYDROXYPROGESTERONE 17-D | Long Descr | Hydroxyprogesterone, 17-d | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 2 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | 77 | Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | GY | Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit | Q4 | Service for ordering/referring physician qualifies as a service exemption | X5 | Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician | XU | Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service |
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| 2023-01-01 | Note | Short description changed. |
| 2013-01-01 | Changed | Description Changed |
| Pre-1990 | Added | Code added. |
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