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Official Description

Estrone

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82679 refers to a laboratory test specifically designed to measure the concentration of estrone, an important estrogen hormone, in the blood. Estrone plays a crucial role in various physiological processes and is particularly significant in the context of reproductive health. In females, this test is utilized to assist in the diagnosis of several medical conditions, including ovarian tumors, Turner's syndrome, and hypopituitarism, which can affect hormonal balance and reproductive function. In males, the measurement of estrone is instrumental in evaluating the underlying causes of gynecomastia, a condition characterized by the enlargement of breast tissue, as well as in detecting estrogen-producing tumors that may influence hormonal levels. The test is performed by obtaining a blood sample through a procedure known as venipuncture, which is separately reportable. The analysis of estrone can be conducted using either plasma or serum samples, and the measurement is typically carried out using mass spectrometry, a highly sensitive and specific analytical technique that allows for accurate quantification of hormone levels in the bloodstream.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The estrone measurement is indicated for various clinical scenarios, particularly in assessing hormonal imbalances and diagnosing specific conditions. The following are the primary indications for performing this laboratory test:

  • Ovarian Tumor The test is utilized to help diagnose the presence of ovarian tumors in females, which can lead to abnormal estrone levels.
  • Turner's Syndrome Estrone measurement aids in the diagnosis of Turner's syndrome, a genetic condition that affects female development and can result in hormonal deficiencies.
  • Hypopituitarism This test is performed to evaluate hypopituitarism in females, a condition where the pituitary gland does not produce sufficient hormones, affecting overall hormonal balance.
  • Gynecomastia In males, estrone levels are measured to determine the cause of gynecomastia, which may be linked to hormonal imbalances or tumors.
  • Estrogen-Producing Tumors The test is also used to detect estrogen-producing tumors in males, which can lead to elevated estrone levels and associated symptoms.

2. Procedure

The procedure for measuring estrone involves several key steps that ensure accurate and reliable results. The following outlines the procedural steps involved:

  • Step 1: Patient Preparation Prior to the blood draw, the patient may be instructed to follow specific guidelines, such as fasting or avoiding certain medications that could affect hormone levels. It is essential to ensure that the patient is adequately prepared for the venipuncture to minimize complications and ensure the integrity of the sample.
  • Step 2: Venipuncture A qualified healthcare professional performs venipuncture to obtain a blood sample. This involves using a sterile needle to access a vein, typically in the arm, and collecting the blood into a designated tube. The procedure is performed with strict adherence to aseptic techniques to prevent contamination and ensure patient safety.
  • Step 3: Sample Handling Once the blood sample is collected, it is crucial to handle it properly to preserve the integrity of the estrone measurement. The sample may be processed to separate plasma or serum, depending on the laboratory's protocols. Proper labeling and storage conditions are also essential to maintain sample viability until analysis.
  • Step 4: Laboratory Analysis The estrone concentration is measured using mass spectrometry, a sophisticated analytical technique that provides high sensitivity and specificity. The laboratory technician prepares the sample for analysis, following established protocols to ensure accurate quantification of estrone levels in the blood.

3. Post-Procedure

After the procedure, patients may experience minimal discomfort at the venipuncture site, which typically resolves quickly. There are generally no specific post-procedure care instructions required for this test, but patients should be advised to monitor the site for any signs of excessive bleeding or infection. Results from the estrone measurement will be interpreted by the healthcare provider in conjunction with the patient's clinical history and other diagnostic tests to determine the appropriate course of action or treatment, if necessary. Follow-up appointments may be scheduled to discuss the results and any further evaluations or interventions that may be warranted based on the findings.

Short Descr ASSAY OF ESTRONE
Medium Descr ASSAY OF ESTRONE
Long Descr Estrone
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) Yes
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GA Waiver of liability statement issued as required by payer policy, individual case
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GW Service not related to the hospice patient's terminal condition
Q4 Service for ordering/referring physician qualifies as a service exemption
QW Clia waived test
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2021-01-01 Note Guidelines changed.
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
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