CPT® Code 82979

The CPT® Code 82979 refers to a laboratory test specifically designed to measure the activity of glutathione reductase (GSR) in red blood cells (RBCs). Glutathione reductase is a crucial flavoprotein enzyme that plays a significant role in cellular defense against oxidative stress by catalyzing the conversion of oxidized glutathione (GSSG) back to its reduced form (GSH). This enzymatic activity is vital for maintaining the integrity of hemoglobin, various red blood cell enzymes, and the membranes of cells, thereby protecting them from potential damage caused by oxidative agents. A deficiency in GSR can lead to conditions such as mild to moderate hemolytic anemia, particularly when exposed to certain drugs or chemicals. Although the activity of GSR is determined by the GSR gene, hereditary deficiencies are exceedingly rare. The test involves obtaining a blood sample through a separate venipuncture procedure, after which the red blood cells are analyzed for GSR activity using a plate-based colorimetric measurement technique.