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The CPT® Code 82979 refers to a laboratory test specifically designed to measure the activity of glutathione reductase (GSR) in red blood cells (RBCs). Glutathione reductase is a crucial flavoprotein enzyme that plays a significant role in cellular defense against oxidative stress by catalyzing the conversion of oxidized glutathione (GSSG) back to its reduced form (GSH). This enzymatic activity is vital for maintaining the integrity of hemoglobin, various red blood cell enzymes, and the membranes of cells, thereby protecting them from potential damage caused by oxidative agents. A deficiency in GSR can lead to conditions such as mild to moderate hemolytic anemia, particularly when exposed to certain drugs or chemicals. Although the activity of GSR is determined by the GSR gene, hereditary deficiencies are exceedingly rare. The test involves obtaining a blood sample through a separate venipuncture procedure, after which the red blood cells are analyzed for GSR activity using a plate-based colorimetric measurement technique.
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The glutathione reductase test (CPT® Code 82979) is indicated for the evaluation of conditions related to oxidative stress and potential hemolytic anemia. The following are specific indications for performing this laboratory test:
The procedure for measuring glutathione reductase activity in red blood cells involves several key steps, which are outlined as follows:
After the glutathione reductase test is completed, there are no specific post-procedure care requirements for the patient. However, it is important to monitor the patient for any potential adverse reactions related to the venipuncture, such as bruising or discomfort at the site of blood draw. The results of the test will be analyzed and reported, providing valuable information regarding the patient's glutathione reductase activity and its implications for their health status. Follow-up consultations may be necessary to discuss the results and any further diagnostic or therapeutic steps that may be indicated based on the findings.
| Short Descr | ASSAY RBC GLUTATHIONE | Medium Descr | ASSAY OF GLUTATHIONE REDUCTASE RBC | Long Descr | Glutathione reductase, RBC | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
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| 2013-01-01 | Changed | Medium Descriptor changed. |
| 2011-01-01 | Changed | Short description changed. |
| Pre-1990 | Added | Code added. |
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