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Official Description

Cyanide

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82600 refers to a laboratory test specifically designed to measure the levels of cyanide in the blood. Cyanide is a highly toxic compound that can be found in various natural sources, including certain seeds and stone fruits, as well as being produced by certain bacteria, fungi, and algae. Additionally, cyanide can be released into the atmosphere as a toxin during the combustion of specific materials. This blood test is crucial for assessing potential cyanide poisoning, which can occur through ingestion or inhalation of cyanide-containing substances. It is important to note that this test should not be conducted on patients who are currently undergoing nitroprusside therapy, as the presence of nitroprusside can lead to inaccurate test results. The procedure for obtaining a blood sample involves a venipuncture, which is a separate reportable service. The analysis of the blood sample is performed using spectrophotometry, a method that measures the amount of light absorbed by the sample, allowing for the quantification of cyanide levels present in the blood.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The cyanide blood test (CPT® Code 82600) is indicated for the evaluation of potential cyanide exposure or poisoning. The following conditions warrant the performance of this test:

  • Potential Cyanide Poisoning This test is performed when there is a suspicion of cyanide toxicity due to ingestion of cyanide-containing seeds or stone fruits, or exposure to atmospheric cyanide from combustion sources.
  • Assessment of Symptoms Symptoms such as headache, dizziness, confusion, or respiratory distress may prompt the need for this test to confirm or rule out cyanide exposure.

2. Procedure

The procedure for conducting the cyanide blood test involves several key steps, which are outlined below:

  • Step 1: Patient Preparation Prior to the test, it is essential to ensure that the patient is not receiving nitroprusside therapy, as this can interfere with the accuracy of the test results. The healthcare provider should confirm the patient's medication history and any potential exposure to cyanide sources.
  • Step 2: Venipuncture A blood sample is obtained through a venipuncture, which involves inserting a needle into a vein, typically in the arm. This step must be performed by a qualified healthcare professional to ensure proper technique and minimize discomfort for the patient.
  • Step 3: Sample Handling After the blood sample is collected, it should be properly labeled and handled according to laboratory protocols to prevent contamination or degradation of the sample prior to analysis.
  • Step 4: Laboratory Analysis The collected blood sample is then analyzed using spectrophotometry. This analytical method measures the absorption of light by the sample, allowing for the quantification of cyanide levels present in the blood.

3. Post-Procedure

After the blood sample has been collected and sent for analysis, there are no specific post-procedure care instructions required for the patient. However, it is important for healthcare providers to monitor the patient for any symptoms of cyanide toxicity, especially if there was a high suspicion of exposure. The results of the test will guide further clinical management and treatment decisions based on the detected cyanide levels.

Short Descr ASSAY OF CYANIDE
Medium Descr ASSAY OF CYANIDE
Long Descr Cyanide
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
Date
Action
Notes
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
Code
Description
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