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The CPT® Code 82627 refers to the laboratory test for measuring dehydroepiandrosterone-sulfate (DHEA-S). DHEA-S is a stable form of the hormone dehydroepiandrosterone (DHEA), which is synthesized primarily in the adrenal glands from cholesterol. Additionally, small quantities of DHEA are produced in the brain, ovaries, and testes. The measurement of DHEA-S is often preferred in clinical settings due to its reduced diurnal variation compared to DHEA, which typically exhibits higher levels in the early morning hours. Elevated concentrations of DHEA-S can be indicative of various medical conditions, including benign adrenal hyperplasia, malignant adrenal tumors, and polycystic ovarian syndrome. Clinically, patients may present with symptoms such as ambiguous external genitalia, precocious puberty in males, and virilization in females. In adult women, elevated DHEA-S levels may manifest as increased body hair, menstrual irregularities, or infertility issues. Conversely, adult males with elevated DHEA-S levels are less likely to exhibit noticeable symptoms. On the other hand, low levels of DHEA-S can adversely affect bone formation, body composition, insulin and glucose metabolism, and may lead to a decrease in libido. The test is performed on a blood sample obtained through venipuncture, and the serum or plasma is analyzed using a quantitative electrochemiluminescent immunoassay method.
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The DHEA-S test is indicated for various clinical scenarios where assessment of adrenal function or androgen levels is necessary. The following conditions may warrant the performance of this laboratory test:
The procedure for obtaining a DHEA-S test involves several key steps to ensure accurate measurement of the hormone levels in the blood. The first step is to prepare the patient for venipuncture, which includes explaining the procedure and ensuring that the patient is comfortable. Following this, a qualified healthcare professional will perform the venipuncture to collect a blood sample. This is typically done by inserting a needle into a vein, usually in the arm, to draw the necessary volume of blood. Once the blood is collected, it is placed in a serum or plasma collection tube, which is then labeled appropriately for identification. The sample is transported to a laboratory where it undergoes analysis. The testing method employed is a quantitative electrochemiluminescent immunoassay, which is a sensitive and specific technique used to measure the concentration of DHEA-S in the serum or plasma. The results of the test are then interpreted by a healthcare provider, who will consider them in the context of the patient's clinical presentation and medical history.
After the DHEA-S test is completed, there are generally no specific post-procedure care requirements for the patient. However, it is advisable for patients to remain hydrated and to follow any additional instructions provided by the healthcare professional. The blood sample will be processed in the laboratory, and results are typically available within a few days. Patients may be advised to schedule a follow-up appointment to discuss the results with their healthcare provider, who will interpret the findings in relation to the patient's symptoms and overall health status. It is important for patients to report any unusual symptoms or concerns following the test, although complications from venipuncture are rare.
| Short Descr | DEHYDROEPIANDROSTERONE | Medium Descr | DEHYDROEPIANDROSTERONE-SULFATE | Long Descr | Dehydroepiandrosterone-sulfate (DHEA-S) | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | Q4 | Service for ordering/referring physician qualifies as a service exemption | GY | Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit | GA | Waiver of liability statement issued as required by payer policy, individual case | GW | Service not related to the hospice patient's terminal condition | 77 | Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | X5 | Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician | 91 | Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient. | 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | 76 | Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | AY | Item or service furnished to an esrd patient that is not for the treatment of esrd | GX | Notice of liability issued, voluntary under payer policy | GZ | Item or service expected to be denied as not reasonable and necessary | PN | Non-excepted service provided at an off-campus, outpatient, provider-based department of a hospital | QW | Clia waived test |
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| 1993-01-01 | Added | First appearance in code book in 1993. |
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