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Official Description

Thiocyanate

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 84430 refers to the laboratory test for measuring thiocyanate levels in blood or urine. Thiocyanate, also known as rhodanide, plays a crucial role in the human host defense system. It is produced during the metabolism of the amino acid cysteine and is involved in the detoxification process of cyanide, a potentially harmful substance. The measurement of thiocyanate levels is significant as elevated levels can indicate exposure to certain environmental factors, such as tobacco use or inhalation of environmental smoke. Additionally, patients receiving the medication nitroprusside may also exhibit increased thiocyanate levels. Conversely, decreased levels of thiocyanate can be observed in individuals suffering from specific diseases, such as cystic fibrosis. The test requires a blood sample, which is obtained through a separately reportable venipuncture procedure, or a urine sample, which can be collected either as a random void or through a 24-hour specimen collection. The analysis of serum, plasma, and urine samples is conducted using quantitative colorimetry, a method that allows for precise measurement of thiocyanate concentrations.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The thiocyanate test (CPT® Code 84430) is indicated for the following conditions:

  • Tobacco Use Elevated thiocyanate levels may be observed in individuals who use tobacco products.
  • Environmental Smoke Exposure Individuals who inhale environmental smoke may also show increased thiocyanate levels.
  • Nitroprusside Administration Patients receiving the drug nitroprusside can exhibit elevated thiocyanate levels due to the drug's metabolism.
  • Cystic Fibrosis Decreased thiocyanate levels may be present in patients diagnosed with cystic fibrosis.

2. Procedure

The procedure for measuring thiocyanate levels involves several key steps:

  • Step 1: Sample Collection A blood sample is obtained through a venipuncture, which is a procedure where a needle is inserted into a vein to draw blood. This step is crucial as it provides the serum or plasma needed for testing. Alternatively, a urine sample can be collected, which may be done as a random void or through a 24-hour specimen collection, depending on the clinical requirements.
  • Step 2: Sample Preparation Once the blood or urine samples are collected, they are prepared for analysis. This may involve centrifugation of the blood sample to separate the serum or plasma from the cellular components, ensuring that only the liquid portion is tested for thiocyanate levels.
  • Step 3: Quantitative Colorimetry The prepared serum, plasma, or urine samples are then analyzed using quantitative colorimetry. This analytical method involves measuring the intensity of color produced in a reaction that correlates with the concentration of thiocyanate in the sample, allowing for accurate quantification of thiocyanate levels.

3. Post-Procedure

After the thiocyanate test is completed, the samples are processed, and results are typically available within a specified timeframe, depending on the laboratory's protocols. Patients may be advised to follow up with their healthcare provider to discuss the results and any necessary further actions. There are generally no specific post-procedure care requirements for patients after blood or urine collection, but they should be informed about any potential side effects from the venipuncture, such as bruising or discomfort at the site of blood draw. Additionally, healthcare providers may consider the clinical context of the thiocyanate levels when planning further diagnostic or therapeutic interventions.

Short Descr ASSAY OF THIOCYANATE
Medium Descr ASSAY OF THIOCYANATE
Long Descr Thiocyanate
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GA Waiver of liability statement issued as required by payer policy, individual case
QW Clia waived test
Date
Action
Notes
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
Code
Description
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