CPT® Code 82585

The CPT® Code 82585 refers to a laboratory test specifically designed to measure cryofibrinogen levels in the blood. Cryofibrinogen is an abnormal protein that precipitates, or forms a solid, when exposed to low temperatures, which can lead to a medical condition known as cryofibrinogenemia (CFG). This condition can be classified into two types: primary and secondary. Primary cryofibrinogenemia is a rare inherited genetic disorder, while secondary cryofibrinogenemia is more prevalent and can arise in patients suffering from various conditions, including non-Hodgkin's lymphoma, colorectal cancer, tuberculosis, herpes viral infections, streptococcal infections, Crohn's disease, systemic lupus erythematosus, and vasculitis. The symptoms associated with CFG are primarily due to vascular occlusion in body areas that are exposed to cold temperatures. Patients may experience a range of symptoms such as skin reactions, including itching, redness, swelling, and hives, as well as purpura rash, skin lesions or ulcers, poor circulation, and phlebitis. Serious complications can arise from this condition, including pulmonary embolism, stroke, myocardial infarctions, and gangrene. To perform the test, a blood sample is collected through a venipuncture, which is a separately reportable procedure. It is crucial that the blood sample is maintained at a temperature of 37 degrees Celsius until it is centrifuged to separate the plasma cells. The plasma is then subjected to qualitative cold precipitation testing to determine the presence and levels of cryofibrinogen.