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The CPT® Code 82585 refers to a laboratory test specifically designed to measure cryofibrinogen levels in the blood. Cryofibrinogen is an abnormal protein that precipitates, or forms a solid, when exposed to low temperatures, which can lead to a medical condition known as cryofibrinogenemia (CFG). This condition can be classified into two types: primary and secondary. Primary cryofibrinogenemia is a rare inherited genetic disorder, while secondary cryofibrinogenemia is more prevalent and can arise in patients suffering from various conditions, including non-Hodgkin's lymphoma, colorectal cancer, tuberculosis, herpes viral infections, streptococcal infections, Crohn's disease, systemic lupus erythematosus, and vasculitis. The symptoms associated with CFG are primarily due to vascular occlusion in body areas that are exposed to cold temperatures. Patients may experience a range of symptoms such as skin reactions, including itching, redness, swelling, and hives, as well as purpura rash, skin lesions or ulcers, poor circulation, and phlebitis. Serious complications can arise from this condition, including pulmonary embolism, stroke, myocardial infarctions, and gangrene. To perform the test, a blood sample is collected through a venipuncture, which is a separately reportable procedure. It is crucial that the blood sample is maintained at a temperature of 37 degrees Celsius until it is centrifuged to separate the plasma cells. The plasma is then subjected to qualitative cold precipitation testing to determine the presence and levels of cryofibrinogen.
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The laboratory test for cryofibrinogen (CPT® Code 82585) is indicated for patients who may be experiencing symptoms associated with cryofibrinogenemia. The following conditions and symptoms warrant the performance of this test:
The procedure for measuring cryofibrinogen involves several critical steps to ensure accurate results. First, a blood sample is obtained from the patient through a venipuncture, which is a standard method of drawing blood from a vein. This step is essential as it provides the necessary specimen for testing. Once the blood is collected, it is crucial to maintain the sample at a temperature of 37 degrees Celsius. This temperature is vital to prevent premature precipitation of cryofibrinogen before the testing process begins. After ensuring the sample is at the correct temperature, the next step involves centrifuging the blood to separate the plasma from the cellular components. This separation is necessary because the test specifically analyzes the plasma for the presence of cryofibrinogen. Following centrifugation, the plasma is subjected to qualitative cold precipitation testing. This testing method involves exposing the plasma to cold temperatures to observe whether cryofibrinogen precipitates out of the solution, indicating its presence and allowing for the measurement of its levels.
After the cryofibrinogen test is completed, the patient may not require any specific post-procedure care, as the venipuncture is a routine procedure with minimal risk. However, it is essential to monitor the patient for any immediate reactions to the blood draw, such as excessive bleeding or bruising at the puncture site. The results of the cryofibrinogen test will be analyzed and reported, providing valuable information regarding the patient's condition. If cryofibrinogen levels are found to be elevated, further clinical evaluation and management may be necessary to address any underlying conditions contributing to the abnormal protein levels. It is important for healthcare providers to discuss the results with the patient and determine any subsequent steps based on the findings.
| Short Descr | ASSAY OF CRYOFIBRINOGEN | Medium Descr | ASSAY OF CRYOFIBRN | Long Descr | Cryofibrinogen | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | GZ | Item or service expected to be denied as not reasonable and necessary |
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| 2013-01-01 | Changed | Medium Descriptor changed. |
| Pre-1990 | Added | Code added. |
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