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Official Description

Fluoride

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82735 refers to the measurement of fluoride levels in the body, which can be assessed through either a blood or urine test. Fluoride, a mineral that occurs naturally in various sources such as drinking water and certain foods, plays a significant role in dental health by helping to reduce the risk of tooth decay. In some communities, fluoride is intentionally added to the drinking water supply to enhance its protective effects against cavities. Additionally, fluoride can be consumed as a dietary supplement for the same purpose. Beyond its dental applications, fluoride is also found in various fluorine-containing compounds, which may be present in pharmaceutical products, pesticides, and other toxic chemicals. The testing process involves obtaining a blood sample through a procedure known as venipuncture, which is separately reportable. For urine testing, a random voided specimen is collected. The analysis of blood fluoride levels is conducted using quantitative ion chromatography, a precise method that quantifies the concentration of fluoride in the sample. In contrast, urine fluoride levels are measured using ion-specific electrode/colorimetry, which allows for the detection of fluoride concentration in the urine. This comprehensive approach to measuring fluoride levels is essential for assessing exposure and potential health impacts associated with fluoride consumption.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The fluoride test (CPT® Code 82735) is indicated for various clinical scenarios where monitoring fluoride levels is essential. The following conditions and situations may warrant this test:

  • Assessment of Fluoride Exposure This test is performed to evaluate an individual's exposure to fluoride, particularly in populations living in areas with fluoridated water supplies or those using fluoride supplements.
  • Monitoring Dental Health The fluoride test can be used to monitor fluoride levels in patients at risk for dental caries, helping to assess the effectiveness of fluoride treatments or supplements.
  • Evaluation of Toxicity In cases of suspected fluoride toxicity, such as accidental ingestion of fluoride-containing products, this test helps determine the fluoride concentration in the body.
  • Research Purposes The test may also be utilized in research settings to study the effects of fluoride on health and its relationship with dental and systemic conditions.

2. Procedure

The procedure for testing fluoride levels involves specific steps to ensure accurate sample collection and analysis. The following outlines the procedural steps:

  • Step 1: Sample Collection for Blood Testing A blood sample is obtained through a process known as venipuncture. This involves the insertion of a needle into a vein, typically in the arm, to draw a sufficient volume of blood for testing. It is important that this step is performed by a trained healthcare professional to minimize discomfort and ensure the integrity of the sample.
  • Step 2: Sample Collection for Urine Testing A urine sample is collected from a random voided specimen. This means that the patient is asked to provide a urine sample at any time during the day, without the need for special preparation or fasting. The random nature of the sample collection helps to reflect the fluoride levels present in the body at that moment.
  • Step 3: Laboratory Analysis of Blood Sample The collected blood sample is then analyzed using quantitative ion chromatography. This laboratory technique allows for the precise measurement of fluoride concentration in the blood, providing valuable information regarding the patient's fluoride exposure.
  • Step 4: Laboratory Analysis of Urine Sample The urine sample is tested using ion-specific electrode/colorimetry. This method enables the detection and quantification of fluoride levels in the urine, which can indicate recent fluoride exposure and help assess overall fluoride metabolism in the body.

3. Post-Procedure

After the fluoride testing procedure, there are generally no specific post-procedure care requirements for patients. However, it is advisable for patients to remain hydrated, especially after urine collection, to facilitate normal bodily functions. The results of the fluoride tests will be interpreted by the healthcare provider, who will discuss the findings with the patient and determine if any further action or follow-up is necessary based on the fluoride levels detected. It is important for patients to communicate any symptoms or concerns they may have, particularly if they suspect fluoride exposure or toxicity.

Short Descr ASSAY OF FLUORIDE
Medium Descr ASSAY OF FLUORIDE
Long Descr Fluoride
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
Date
Action
Notes
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
Code
Description
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